Epigenetic profiling for the molecular classification of metastatic brain tumors
نویسندگان
چکیده
منابع مشابه
Classification of Primary Brain Tumors: Molecular Aspects
The guiding principle of this chapter is the importance of combining traditional morphological data with the recently acquired knowledge on the genetic and epigenetic signalling pathways which drive the evolution of CNS tumors. The official World Health Organization terminology (WHO, 2007) will be used since it is the source of information for neurooncology, neuroradiology, neurosurgery, etc. I...
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Background: Early diagnosis of brain tumors has significant effect on the treatment process. Brain metastatic tumors are usually diagnosed following the neurological symptoms in patients or incidentally after Computerized Tomography (CT) scan and Magnetic Resonance Imaging (MRI) requests of the brain. Objectives: Implementation of a new method for being informed about the origin of brain tumors...
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The new, simple, and reliable method for the diagnosis of brain tumors is described. It is based on a TLC quantitative determination of 5-methylcytosine (m(5)C) in relation to its damage products of DNA from tumor tissue. Currently, there is evidence that oxidative stress through reactive oxygen species (ROS) plays an important role in the etiology and progression of several human diseases. Oxi...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2018
ISSN: 2041-1723
DOI: 10.1038/s41467-018-06715-y